Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.050 Biomarker disease BEFREE • Combining metabolical and morphological features using<sup>18</sup>F-FDG PET/CT improves the detection of malignant lymph node in patients with bladder cancer. 30666449 2019
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.100 Biomarker disease BEFREE  Effect of siRNA targeting EZH2 on cell viability and apoptosis of bladder cancer T24 cells. 25501205 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE [Science (Washington DC), 252: 706-709, 1991] showing that p53 gene mutations were frequently found in invasive bladder cancers by sequence analysis on polymerase chain reaction amplified products corresponding to exons 5 to 9. 1540947 1992
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Zymography revealed higher levels of MMP-9 activity in the ovarian cancer biopsy samples than in other cancers studied, but in contrast to our previous observations in breast and bladder cancer, there was no correlation between MMP levels and tumor grade. 8014015 1994
Entrez Id: 6624
Gene Symbol: FSCN1
FSCN1
0.040 AlteredExpression disease BEFREE ZEB1-AS1 functions as a competing endogenous RNA in BLCA to regulate the expression of fascin-1 through miR-200b. 30823924 2019
Entrez Id: 9201
Gene Symbol: DCLK1
DCLK1
0.020 Biomarker disease BEFREE Yet, there are limited reports on the role of DCLK1 as a putative CSC marker in bladder cancer. 31028726 2019
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
0.100 Biomarker disease BEFREE XPD and XRCC1 appear to have no impact on the risk of bladder cancer. 11304692 2001
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.050 AlteredExpression disease BEFREE XPC deficiency leads to centrosome amplification by inhibiting BRCA1 expression upon cisplatin-mediated DNA damage in human bladder cancer. 30579971 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE XIAP Interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion. 31811115 2019
Entrez Id: 1869
Gene Symbol: E2F1
E2F1
0.090 Biomarker disease BEFREE XIAP Interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion. 31811115 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell. 28057023 2017
Entrez Id: 406983
Gene Symbol: MIR200A
MIR200A
0.040 AlteredExpression disease BEFREE XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell. 28057023 2017
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.020 AlteredExpression disease BEFREE XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell. 28057023 2017
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE Xeroderma pigmentosum complementation group D (XPD) gene polymorphisms contribute to bladder cancer risk: a meta-analysis. 24347488 2014
Entrez Id: 283624
Gene Symbol: LINC00641
LINC00641
0.020 AlteredExpression disease BEFREE Xenograft assay also confirmed that LINC00641 overexpression suppressed bladder cancer growth in vivo. 30060954 2018
Entrez Id: 2463
Gene Symbol: FRA16D
FRA16D
0.010 AlteredExpression disease BEFREE WW domain-containing oxidoreductase (WWOX) gene located in the common fragile site FRA16D region exhibits loss or reduction of expression in multiple types of carcinomas including bladder cancer. 27352332 2015
Entrez Id: 442919
Gene Symbol: MIR374A
MIR374A
0.010 Biomarker disease BEFREE WNT5A was a direct target of miR-374a in two bladder cancer cell lines. miR-374a mimic abrogated the metastatic potential and invasiveness of bladder cancer cells via WNT5A downregulation in both T24 and TCCSUP human bladder cancer cells; the opposite was observed with miR-374a inhibitor. 30032142 2018
Entrez Id: 142
Gene Symbol: PARP1
PARP1
0.040 GeneticVariation disease BEFREE Without adjustment for multiple testing, multivariate analysis demonstrated an association with increased bladder cancer risk with PARP1 rs8679 (P(trend) = 0.05) while variant homozygotes of PARP1 rs8679 were also noted to have an increased breast cancer risk (P = 0.03). 22166496 2012
Entrez Id: 1544
Gene Symbol: CYP1A2
CYP1A2
0.090 GeneticVariation disease BEFREE Within the framework of a hospital-based case/control study, we investigated the relationship between CYP1A2 polymorphisms, occupational/environmental exposures and bladder cancer (BC) risk. 20559687 2010
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.040 Biomarker disease BEFREE WITHDRAWN: Long non-coding RNA UCA1 regulates tumor growth by impairing let-7e-dependent HMGA2 repression in bladder cancer. 31306103 2019
Entrez Id: 406887
Gene Symbol: MIRLET7E
MIRLET7E
0.010 Biomarker disease BEFREE WITHDRAWN: Long non-coding RNA UCA1 regulates tumor growth by impairing let-7e-dependent HMGA2 repression in bladder cancer. 31306103 2019
Entrez Id: 4907
Gene Symbol: NT5E
NT5E
0.040 Biomarker disease BEFREE With the aim of using ecto-5'-nucleotidase/CD73 as a predictive biomarker, the role of this enzyme in the context of radiotherapy in T24 human bladder cancer cell line was investigated. 29305710 2018
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.080 GeneticVariation disease BEFREE With respect to the stage of BC, the AA genotype of SDF-1 and at least one T allele of CXCR4 were significantly associated with high T stage as compared to GG genotype of SDF-1 and CC genotype of CXCR4. 22982413 2012
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.070 GeneticVariation disease BEFREE With respect to the stage of BC, the AA genotype of SDF-1 and at least one T allele of CXCR4 were significantly associated with high T stage as compared to GG genotype of SDF-1 and CC genotype of CXCR4. 22982413 2012
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 Biomarker disease BEFREE With regard to BC, an overall odds ratio (OR) of 2.07 [95% confidence interval (CI): 1.38-3.09] for those with GSTM1 and an OR of 2.07 (95% CI: 1.38-3.09) for those with GSTT1 null genotype were reported when exposed to polycyclic aromatic hydrocarbons (PAHs). 28403014 2018